By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This booklet is the 7th quantity within the sequence "Acute publicity guide degrees for chosen Airborne Chemicals", and contains AEGLs for acetone cyanohydrin, carbon disulfide, monochloroacetic acid, and phenol. on the request of the dept of security, the nationwide study Council has reviewed the proper medical literature compiled via knowledgeable panel and proven Acute publicity instruction degrees (AEGLs) for 12 new chemical substances. AEGLs signify publicity degrees less than which antagonistic healthiness results aren't more likely to ensue and are invaluable in responding to emergencies akin to unintentional or intentional chemical releases locally, the office, transportation, the army, and for the remediation of infected websites. 3 AEGLs are licensed for every chemical, representing publicity degrees that lead to: striking yet reversible ache; long-lasting well-being results; and, life-threatening health and wellbeing affects.
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Additional info for Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7
The incidence of malformations and developmental variations for all fetuses of treated animals were comparable with the concurrent control group fetuses. 4. Genotoxicity In tests using different Salmonella strains, acetone cyanohydrin failed to yield a reproducible positive response. No mutagenic activity was observed in 27 Acetone Cyanohydrin vitro using the Chinese hamster ovary (CHO) gene mutation assay. I. du Pont de Nemours and Co. 1998). 5. Carcinogenicity No information regarding the carcinogenic potential of acetone cyanohydrin exposure was located in the available literature.
A concentrationresponse relationship corresponding to high- and low-exposure jobs was demonstrated, but exact breathing zone concentrations were not quantified. Some symptoms exhibiting a dose-response trend occurring 7 or more months after exposure had ceased. Mild abnormalities of vitamin B12, folate, and thyroid function were detected, and those results suggested cyanide and/or thiocyanide involvement. The NRC (2000) pointed out that the 24-h TWA of 15 ppm was measured 1 day after the plant had ceased operation, suggesting that these workers may have been exposed to cyanide at more than 15 ppm.
There were no adverse effects of inhaled acetone cyanohydrin in males as indicated by mortality, mean body weights (the high-exposure group showed a lower mean body weight, which was not significantly different from that of the concurrent control group), clinical observations and necropsy (males were killed about 3 weeks after the end of the exposure period). The number of live implants and pre- and post-implantation losses were comparable for females mated with untreated or treated males. The authors concluded that exposure to acetone cyanohydrin at 60 ppm failed to demonstrate any potential for reproductive toxicity in male rats.