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By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Governme

Traditionally, laws governing chemical use have frequently involved in universal chemical substances and acute human overall healthiness results of publicity to them, in addition to their capability to reason melanoma and different antagonistic overall healthiness results. As clinical wisdom has increased there was an elevated understanding of the mechanisms during which chemical substances might exert destructive results on human overall healthiness, in addition to their results on other  Read more...

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A life cycle assessment step has been included in the committee’s framework to support conducting such analyses when needed (as determined in Step 8) and to meet the objective in the task statement, which states that the framework should be able to balance other relevant considerations, such as resource use, with human health and ecological hazards. This step is also consistent with other frameworks. It should be noted that the goal of this step is to assess the relative life cycle impacts of alternatives to uncover trade-offs that might need to be considered and resolved in later decision steps (Step 10).

Frameworks: BizNGO, CA SCP, REACH, and UNEP This step is an early decision point to determine if alternatives to evaluate further are available. Four frameworks allow or encourage the development of new or improved alternatives when alternatives are not available or those available could be improved. Similarly, this early step has been included in the committee’s framework to address those situations so that the process for developing safer substitutes (Step 13) can be initiated earlier. Chapter 13 has a more complete discussion on innovation and the design of safer chemical substitutes.

2011) is intended to help business enterprises systematically implement sustainable chemistry in their daily practice. Published in 2011, it includes specific guidelines for evaluating intrinsic chemical hazards and analyzing social and life cycle impacts (OECD 2013a). Interstate Chemicals Clearinghouse (IC2) Alternatives Assessment Guide: The Interstate Chemicals Clearinghouse’s (IC2) developed the Alternatives Assessment Guide (IC2 2013) based on input from experts from California, Connecticut, Michigan, Minnesota, New York, and Oregon and is funded by a grant from the EPA to Washington State.

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